Tag: Structural Biochemistry

  • Decoding ADAR1: how an RNA editor may unlock therapeutic potential

    Decoding ADAR1: how an RNA editor may unlock therapeutic potential

    In a fresh advance with implications for cancer, autoimmunity, and RNA therapeutics, a team led by Yang Gao at Rice University has peeled back key molecular mechanisms of ADAR1, a protein that edits RNA to prevent inappropriate immune signaling. Their work provides structural and biochemical insight into how ADAR1 distinguishes and binds RNA substrates—insights that…