Tag: NEAT1

  • The Molecular Switch That Guards the Neuron: TDP-43 and the Architecture of Paraspeckle Condensates

    The Molecular Switch That Guards the Neuron: TDP-43 and the Architecture of Paraspeckle Condensates

    The cell nucleus is a highly organized environment in which the biological activity of genes is not simply the product of DNA sequences and proteins, but also of the three-dimensional spatial compartmentalization that governs where, when, and how molecular events unfold. Among the most compelling features of nuclear architecture are the membraneless organelles—dynamic, protein-rich condensates…