Tag: m5C

  • Writing on RNA: How a Single Enzyme Decides Which Messages to Methylate

    Writing on RNA: How a Single Enzyme Decides Which Messages to Methylate

    Among the more than 150 chemically distinct modifications that have been identified in cellular RNA, 5-methylcytosine — abbreviated m5C — has long occupied an ambiguous position in the landscape of epitranscriptomics. Present in transfer RNAs, messenger RNAs, and several non-coding RNA species, m5C is deposited by a family of enzymes whose biological importance has become…