Tag: #GeneTherapy
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One of the most persistent challenges in gene and cell therapy is not simply delivering a therapeutic gene to the right cell — it is ensuring that, once delivered, the gene’s expression can be turned on and off with sufficient precision to remain both safe and effective over time. Current inducible systems, which allow researchers…
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Base-Edited CAR T-Cell Therapy Achieves Remission in Refractory T-Cell Leukemia The therapeutic armamentarium against hematological malignancies has been substantially enriched through the clinical implementation of BE-CAR7, a pioneering base-edited chimeric antigen receptor T-cell therapy targeting T-cell acute lymphoblastic leukemia. Announced this December by investigators at University College London and Great Ormond Street Hospital, this therapeutic…