Tag: #FANCJ

  • FANCJ and the DNA Knots It Unties: A Structural Blueprint for a Cancer-Linked Helicase

    FANCJ and the DNA Knots It Unties: A Structural Blueprint for a Cancer-Linked Helicase

    Guanine-rich DNA can fold back on itself into four-stranded knots called G-quadruplexes, or G4s — structures that help regulate gene expression and telomere biology but that stall replication forks if left unresolved. The helicase FANCJ is one of the cell’s principal G4-resolving enzymes, and its gene doubles as a Fanconi anemia locus and a hereditary…