Tag: #ElongatorComplex

  • A Molecular Tunnel at the Heart of Translation: How Elp3 Rewrites the Rules of tRNA Modification

    A Molecular Tunnel at the Heart of Translation: How Elp3 Rewrites the Rules of tRNA Modification

    Transfer RNA is among the most chemically decorated molecules in the cell — an average human tRNA carries more than a dozen distinct post-transcriptional modifications, each one placed with exquisite precision to fine-tune its performance on the ribosome. Among these, the family of 5-carboxymethyluridine (cm⁵U) modifications at the wobble position of the anticodon holds particular…