Tag: #cryoEM

  • FANCJ and the DNA Knots It Unties: A Structural Blueprint for a Cancer-Linked Helicase

    FANCJ and the DNA Knots It Unties: A Structural Blueprint for a Cancer-Linked Helicase

    Guanine-rich DNA can fold back on itself into four-stranded knots called G-quadruplexes, or G4s — structures that help regulate gene expression and telomere biology but that stall replication forks if left unresolved. The helicase FANCJ is one of the cell’s principal G4-resolving enzymes, and its gene doubles as a Fanconi anemia locus and a hereditary…

  • GPR84 and the Anatomy of Bias: A Structural Blueprint for Safer Anti-Inflammatory Drugs

    GPR84 and the Anatomy of Bias: A Structural Blueprint for Safer Anti-Inflammatory Drugs

    GPR84 belongs to a peculiar category of cell-surface receptors: it is an orphan G protein–coupled receptor (GPCR), meaning that although it is known to respond to medium-chain fatty acids released during metabolic and inflammatory stress, its physiological ligand repertoire remains only partially defined. Expressed predominantly on macrophages, neutrophils, and other cells of the innate immune…