Tag: CRISPR
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CRISPR technology reached a historic milestone in late 2023 when the Food and Drug Administration (FDA) granted its first approval for clinical application . This groundbreaking authorization marked a pivotal moment in genetic medicine, allowing the CRISPR-Cas9 drug Casgevy® (exagamglogene autotemcel) to treat both sickle cell disease and transfusion-dependent beta thalassemia . The clinical results…
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Di Paolo Rega In un importante passo avanti per l’ingegneria genetica e l’immunoterapia, un gruppo di ricercatori del Karolinska Institutet ha sviluppato un innovativo sistema CRISPR optogenetico che consente di modificare i geni nei linfociti T in modo preciso e controllato tramite la luce — persino all’interno di organismi viventi. Il sistema, chiamato BLU-VIPR (Blue…
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By Paolo Rega In a groundbreaking advance for genetic engineering and immunotherapy, researchers at the Karolinska Institutet have unveiled a novel optogenetic CRISPR system that enables precise, light-controlled gene editing in T lymphocytes — even inside living organisms. The system, dubbed BLU-VIPR (Blue Light-inducible Universal VPR-Improved Production of RGRs), allows scientists to turn gene editing…
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In the realm of genetic medicine, where breakthroughs often pave the way for revolutionary treatments, a new genomic technique has emerged, promising to complement the strides made with the CRISPR-Cas technology. Recently published in the prestigious journal Nature Biotechnology, a study titled “Harnessing Eukaryotic Retroelement Proteins for Transgene Insertion into Human Safe-Harbor Loci” unveils the…